colorectal cancer

2 curated biomarkers

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FDA-approved treatments

BRAF
- Tafinlar (dabrafenib) [fda]
- Braftovi (encorafenib) [fda]
- Zelboraf (vemurafenib) [fda]
KRAS
- Krazati (adagrasib) [fda]
- Lumakras (sotorasib) [fda]

Prevalence

BRAF
BRAF V600E mutations occur in approximately 50% of cutaneous melanomas, 8%-15% of colorectal cancers, and 1%-3% of NSCLC.[fda]
KRAS
KRAS mutations occur in approximately 25% of NSCLC and up to 45% of colorectal cancers; KRAS G12C specifically accounts for approximately 13% of NSCLC and 3%-4% of colorectal cancer cases.[fda]

Tests / detection method

BRAF
PCR-based mutation assays, NGS
KRAS
NGS

Therapeutic pipeline

BRAF
- Class II/III BRAF-selective inhibitors targeting non-V600 alterations (non-V600 BRAF alterations) [fda]
KRAS
- KRAS G12D and pan-RAS/multi-RAS inhibitors (KRAS G12D, KRAS G12V) [fda]

PubMed Central · Oct 1, 2026
Factors Affecting Postoperative Delirium in Patients With Colorectal Cancer.
Read at PubMed Central
PubMed Central · Oct 1, 2026
Tumor Suppressive Role of Hsa-miR-328-3p in Colon Cancer by Regulating EN2.
Read at PubMed Central
PubMed Central · Oct 1, 2026
Multicohort Construction, Immune Landscape Analysis, and PCOLCE2 Functional Validation of an Inflammation-Related Prognostic Model in Colorectal Cancer.
Read at PubMed Central
PubMed Central · Oct 1, 2026
A Functionally Constrained Immune Ecosystem in Microsatellite-stable Colorectal Cancer Resolved by Single-cell and Exome Profiling.
Read at PubMed Central
PubMed Central · Oct 1, 2026
Multi-omics Investigations of Immune Microenvironment of Human Colorectal Cancer.
Read at PubMed Central
PubMed Central · Sep 4, 2026
Evaluation of Programmed Death Ligand-1 (PD-L1) and B-cell Lymphoma 2 (BCL2) protein expression using immunohistochemistry in colorectal carcinoma patients from Anbar Governorate.
- PD-L1 (biomarker)
Read at PubMed Central
PubMed Central · Sep 4, 2026
Pharmacological inhibition of the canonical Wnt/β-catenin signaling pathway sensitizes 5-fluorouracil-resistant colorectal cancer cells.
Read at PubMed Central
PubMed Central · Sep 2, 2026
KRAS Inhibitor-Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones.
- KRAS (biomarker)
Read at PubMed Central
PubMed Central · Sep 2, 2026
MR-based radiomics of mesorectal fat for improved prediction of perirectal lymph node metastasis and extramural venous invasion in locally advanced rectal cancer.
Read at PubMed Central
PubMed Central · Sep 2, 2026
KRAS is required for plexiform neurofibroma formation and represents a targetable vulnerability in established tumors.
- KRAS (biomarker)
Read at PubMed Central
PubMed Central · Sep 2, 2026
Preoperative CT-based 3D analysis of middle colic vein anatomy for complete mesocolic excision in right-sided colon cancer: a retrospective cohort study from a prospective clinical trial.
Read at PubMed Central
PubMed Central · Sep 2, 2026
Overall survival of immunotherapy versus standard of care in chemorefractory microsatellite stable metastatic colorectal cancer: a propensity score matched analysis of 708 patients.
Read at PubMed Central
PubMed Central · Sep 1, 2026
The Landscape of Genomic and Socioeconomic Variables in Patients with Colorectal Cancer Based on Genetic Ancestry.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Energy Balance-Related Factors and Direct Tumor-Adipocyte Contact in Colorectal Cancer: Etiologic Insights from the Population-Based Netherlands Cohort Study.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Timeliness of Colorectal Cancer Care in Veterans: The Role of Travel Distance.
Read at PubMed Central
PubMed Central · Sep 1, 2026
First-line anlotinib versus bevacizumab plus CapeOX in RAS/BRAF wild-type unresectable metastatic colorectal cancer (ANCHOR): a multicenter, prospective, randomized, phase 3 trial.
- BRAF (biomarker)
Read at PubMed Central
PubMed Central · Sep 1, 2026
Patterns of Multimorbidity among Older Adults with Colorectal Cancer Living in Puerto Rico.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703).
Read at PubMed Central
PubMed Central · Sep 1, 2026
Real-world clinical impact of implementing and updating a deep learning-based automatic contouring system in rectal cancer radiotherapy.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Anterior Cutaneous Nerve Entrapment Syndrome in a 51-Year-Old Woman With Advanced Colon Cancer, Successfully Treated With Repeated Ultrasound-Guided Rectus Sheath Blocks: A Case Report.
Read at PubMed Central

colorectal cancer

FDA-approved treatments

Prevalence

Tests / detection method

Therapeutic pipeline

Recent news for colorectal cancer

Factors Affecting Postoperative Delirium in Patients With Colorectal Cancer.

Tumor Suppressive Role of Hsa-miR-328-3p in Colon Cancer by Regulating EN2.

Multicohort Construction, Immune Landscape Analysis, and PCOLCE2 Functional Validation of an Inflammation-Related Prognostic Model in Colorectal Cancer.

A Functionally Constrained Immune Ecosystem in Microsatellite-stable Colorectal Cancer Resolved by Single-cell and Exome Profiling.

Multi-omics Investigations of Immune Microenvironment of Human Colorectal Cancer.

Evaluation of Programmed Death Ligand-1 (PD-L1) and B-cell Lymphoma 2 (BCL2) protein expression using immunohistochemistry in colorectal carcinoma patients from Anbar Governorate.

Pharmacological inhibition of the canonical Wnt/β-catenin signaling pathway sensitizes 5-fluorouracil-resistant colorectal cancer cells.

KRAS Inhibitor-Induced Cancer Cell Death Enhances Sensitivity to Immune-Mediated Bystander Killing of Drug-Resistant Subclones.

MR-based radiomics of mesorectal fat for improved prediction of perirectal lymph node metastasis and extramural venous invasion in locally advanced rectal cancer.

KRAS is required for plexiform neurofibroma formation and represents a targetable vulnerability in established tumors.

Preoperative CT-based 3D analysis of middle colic vein anatomy for complete mesocolic excision in right-sided colon cancer: a retrospective cohort study from a prospective clinical trial.

Overall survival of immunotherapy versus standard of care in chemorefractory microsatellite stable metastatic colorectal cancer: a propensity score matched analysis of 708 patients.

The Landscape of Genomic and Socioeconomic Variables in Patients with Colorectal Cancer Based on Genetic Ancestry.

Energy Balance-Related Factors and Direct Tumor-Adipocyte Contact in Colorectal Cancer: Etiologic Insights from the Population-Based Netherlands Cohort Study.

Timeliness of Colorectal Cancer Care in Veterans: The Role of Travel Distance.

First-line anlotinib versus bevacizumab plus CapeOX in RAS/BRAF wild-type unresectable metastatic colorectal cancer (ANCHOR): a multicenter, prospective, randomized, phase 3 trial.

Patterns of Multimorbidity among Older Adults with Colorectal Cancer Living in Puerto Rico.

Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703).

Real-world clinical impact of implementing and updating a deep learning-based automatic contouring system in rectal cancer radiotherapy.

Anterior Cutaneous Nerve Entrapment Syndrome in a 51-Year-Old Woman With Advanced Colon Cancer, Successfully Treated With Repeated Ultrasound-Guided Rectus Sheath Blocks: A Case Report.