melanoma

1 curated biomarker

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FDA-approved treatments

BRAF
- Tafinlar (dabrafenib) [fda]
- Braftovi (encorafenib) [fda]
- Zelboraf (vemurafenib) [fda]

Prevalence

BRAF
BRAF V600E mutations occur in approximately 50% of cutaneous melanomas, 8%-15% of colorectal cancers, and 1%-3% of NSCLC.[fda]

Tests / detection method

BRAF
PCR-based mutation assays, NGS

Therapeutic pipeline

BRAF
- Class II/III BRAF-selective inhibitors targeting non-V600 alterations (non-V600 BRAF alterations) [fda]

PubMed Central · Oct 1, 2026
Anti-gicerin Antibody Suppresses Early Pulmonary Metastatic Colonization of B16F10 Melanoma Cells.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Intratumoral Sotigalimab with Pembrolizumab Induces Rapid Activation of Antigen-Presenting Cells and Drives Antitumor Responses in Non-injected Tumors in Metastatic Melanoma: A Phase I/II Study.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Cellular Neighborhoods Govern Antitumor T-cell Infiltration Following Anti-CTLA-4 in Melanoma with Primary Resistance to Anti-PD-1.
Read at PubMed Central
PubMed Central · Sep 1, 2026
A Technique for the Generation of Mucosal and Acral Melanoma Cell Lines.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Fatty Acid-Binding Protein 5 Potentially Regulates the Proliferation and Metastasis of Uveal Melanoma Cells Through the PI3K/AKT/mTOR Signaling Pathway.
Read at PubMed Central
PubMed Central · Sep 1, 2026
Demographic, Clinicopathological Characteristics, and Prognosis of 81 Chinese Elderly Patients With Acral Melanoma.
Read at PubMed Central
PubMed Central · Aug 28, 2026
Effects on mouse melanoma and immune cells of P2X7 receptor positive allosterism by clemastine.
Read at PubMed Central
PubMed Central · Aug 28, 2026
Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.
Read at PubMed Central
PubMed Central · Aug 27, 2026
Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability.
Read at PubMed Central
PubMed Central · Aug 27, 2026
New TRPM8 Amino Acid-Based Antagonists Induce Antiproliferative Effect on 2D and 3D Melanoma and Prostate Cancer Models.
- prostate cancer (tumour type)
Read at PubMed Central
PubMed Central · Aug 25, 2026
What's Trending: Cross-Sectional Analysis of the Content and Quality of Popular Melanoma Videos on TikTok.
Read at PubMed Central
PubMed Central · Aug 21, 2026
A Coordinated Approach to Perioperative Rehabilitation to Enhance Outcomes in Melanoma: Protocol for the CARE-Melanoma Pilot Randomized Controlled Trial.
Read at PubMed Central
PubMed Central · Aug 20, 2026
A multiscale geospatial analysis integrating explainable machine learning to characterize spatial disparities in melanoma mortality associated with environmental justice and healthcare access in the contiguous United States.
Read at PubMed Central
PubMed Central · Aug 20, 2026
Immune-cytokine signature predicts survival in patients with advanced melanoma treated with oncolytic adenovirus TILT-123 and chemotherapy and IL-2-free adoptive TIL therapy.
Read at PubMed Central
PubMed Central · Aug 19, 2026
pAc/Emm55 increases anti-melanoma immunity via TLR2 signaling in dendritic cells and improves checkpoint blockade efficacy.
Read at PubMed Central
PubMed Central · Aug 19, 2026
Complete tumour regression of in-transit melanoma following discontinuation of talimogene laherparepvec.
Read at PubMed Central
PubMed Central · Aug 19, 2026
Risk of Second Primary Cancers in Melanoma Survivors: A Retrospective Hospital-Based Cohort Study from Two Romanian Referral Centres.
Read at PubMed Central
PubMed Central · Aug 19, 2026
Systemic surveillance for uveal melanoma: Approach to optimization.
Read at PubMed Central
PubMed Central · Aug 14, 2026
Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multiselective Inhibitors in NRAS-Mutated Melanoma.
Read at PubMed Central
PubMed Central · Aug 14, 2026
GDF15 Reprograms the Microenvironment to Drive Liver Metastasis of Uveal Melanoma.
Read at PubMed Central

melanoma

FDA-approved treatments

Prevalence

Tests / detection method

Therapeutic pipeline

Recent news for melanoma

Anti-gicerin Antibody Suppresses Early Pulmonary Metastatic Colonization of B16F10 Melanoma Cells.

Intratumoral Sotigalimab with Pembrolizumab Induces Rapid Activation of Antigen-Presenting Cells and Drives Antitumor Responses in Non-injected Tumors in Metastatic Melanoma: A Phase I/II Study.

Cellular Neighborhoods Govern Antitumor T-cell Infiltration Following Anti-CTLA-4 in Melanoma with Primary Resistance to Anti-PD-1.

A Technique for the Generation of Mucosal and Acral Melanoma Cell Lines.

Fatty Acid-Binding Protein 5 Potentially Regulates the Proliferation and Metastasis of Uveal Melanoma Cells Through the PI3K/AKT/mTOR Signaling Pathway.

Demographic, Clinicopathological Characteristics, and Prognosis of 81 Chinese Elderly Patients With Acral Melanoma.

Effects on mouse melanoma and immune cells of P2X7 receptor positive allosterism by clemastine.

Store-operated calcium signaling modulators improve a dendritic cell-based vaccine against melanoma.

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability.

New TRPM8 Amino Acid-Based Antagonists Induce Antiproliferative Effect on 2D and 3D Melanoma and Prostate Cancer Models.

What's Trending: Cross-Sectional Analysis of the Content and Quality of Popular Melanoma Videos on TikTok.

A Coordinated Approach to Perioperative Rehabilitation to Enhance Outcomes in Melanoma: Protocol for the CARE-Melanoma Pilot Randomized Controlled Trial.

A multiscale geospatial analysis integrating explainable machine learning to characterize spatial disparities in melanoma mortality associated with environmental justice and healthcare access in the contiguous United States.

Immune-cytokine signature predicts survival in patients with advanced melanoma treated with oncolytic adenovirus TILT-123 and chemotherapy and IL-2-free adoptive TIL therapy.

pAc/Emm55 increases anti-melanoma immunity via TLR2 signaling in dendritic cells and improves checkpoint blockade efficacy.

Complete tumour regression of in-transit melanoma following discontinuation of talimogene laherparepvec.

Risk of Second Primary Cancers in Melanoma Survivors: A Retrospective Hospital-Based Cohort Study from Two Romanian Referral Centres.

Systemic surveillance for uveal melanoma: Approach to optimization.

Genetic Drivers of Sensitivity or Resistance to RAS(ON) Multiselective Inhibitors in NRAS-Mutated Melanoma.

GDF15 Reprograms the Microenvironment to Drive Liver Metastasis of Uveal Melanoma.